| 2. Round | 07/08/2021 | Cobán Imperial | - | Sololá FC | 0:0 |  |
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| 4. Round | 14/08/2021 | Cobán Imperial | - | Achuapa | 2:0 | ||||
| 3. Round | 18/08/2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | |
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| 5. Round | 22/08/2021 | Comunicaciones | - | Cobán Imperial | 2:2 | ||||
| 9. Round | 11/09/2021 | Cobán Imperial | - | Santa Lucía | 0:1 | ||||
| 10. Round | 18/09/2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 11. Round | 25/09/2021 | Cobán Imperial | - | Iztapa | 2:1 | ||||
| 12. Round | 02/10/2021 | Cobán Imperial | - | Xelaju MC | 1:1 | |
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| 13. Round | 10/10/2021 | Sololá FC | - | Cobán Imperial | 1:2 | ||||
| 8. Round | 13/10/2021 | Deportivo Guastatoya | - | Cobán Imperial | 0:1 |  |
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| 14. Round | 17/10/2021 | Cobán Imperial | - | Nueva Concepción | 2:0 | |
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| 16. Round | 27/10/2021 | Cobán Imperial | - | Comunicaciones | 1:2 | ||||
| 17. Round | 31/10/2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 19. Round | 13/11/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | |
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| 20. Round | 20/11/2021 | Santa Lucía | - | Cobán Imperial | 2:2 | |
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| 22. Round | 05/12/2021 | Iztapa | - | Cobán Imperial | 5:3 | |
Guatemala
Canada