| 2. Round | 15/02/2022 | Deportivo Binacional | - | Academia Cantolao | 5:0 | ||||
| 3. Round | 20/02/2022 | Academia Cantolao | - | Alianza Atlético | 1:3 | ||||
| 4. Round | 26/02/2022 | Atlético Grau | - | Academia Cantolao | 1:0 | ||||
| 5. Round | 06/03/2022 | Academia Cantolao | - | Mannucci | 3:2 | ||||
| 6. Round | 13/03/2022 | Sporting Cristal | - | Academia Cantolao | 2:2 |  |
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| 7. Round | 20/03/2022 | Academia Cantolao | - | FBC Melgar | 0:1 | |
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| 9. Round | 09/04/2022 | Academia Cantolao | - | Sport Huancayo | 0:2 | ||||
| 10. Round | 15/04/2022 | Universidad Técnica | - | Academia Cantolao | 2:2 | ||||
| 11. Round | 23/04/2022 | Academia Cantolao | - | Alianza Lima | 1:2 | |
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| 13. Round | 08/05/2022 | Carlos Stein | - | Academia Cantolao | 2:1 | ||||
| 14. Round | 14/05/2022 | Academia Cantolao | - | Universidad San Martín | 2:2 | |
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| 17. Round | 18/06/2022 | Cienciano | - | Academia Cantolao | 1:0 | ||||
| 18. Round | 26/06/2022 | Academia Cantolao | - | AD Tarma | 3:0 | |
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| 19. Round | 01/07/2022 | Ayacucho FC | - | Academia Cantolao | 1:2 |
Peru