| 2. Round | 01/08/2021 | Jicaral | - | CS Herediano | 3:2 | ||||
| 3. Round | 08/08/2021 | Municipal Grecia | - | Jicaral | 0:0 | ||||
| 5. Round | 14/08/2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 6. Round | 21/08/2021 | Jicaral | - | Santos de Guápiles | 1:1 | ||||
| 7. Round | 25/08/2021 | Deportivo Saprissa | - | Jicaral | 4:0 | ||||
| 8. Round | 28/08/2021 | Jicaral | - | Guadalupe | 0:0 | ||||
| 4. Round | 01/09/2021 | Jicaral | - | Sporting FC | 1:3 | ||||
| 10. Round | 12/09/2021 | AD Guanacasteca | - | Jicaral | 1:1 | ||||
| 11. Round | 15/09/2021 | Jicaral | - | CS Cartaginés | 0:3 |  |
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| 20. Round | 21/11/2021 | Jicaral | - | LD Alajuelense | 0:3 | ||||
| 21. Round | 24/11/2021 | Jicaral | - | AD Guanacasteca | 2:2 | ||||
| 22. Round | 28/11/2021 | CS Cartaginés | - | Jicaral | 4:0 | |
Costa Rica