| 1. Round | 19/07/2021 | Universidad Cesar Vallejo | - | Cusco FC | 1:0 | ||||
| 3. Round | 01/08/2021 | Cusco FC | - | Alianza Universidad | 2:3 | ||||
| 4. Round | 04/08/2021 | FBC Melgar | - | Cusco FC | 2:2 | ||||
| 7. Round | 17/08/2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 8. Round | 23/08/2021 | Sporting Cristal | - | Cusco FC | 4:1 | ||||
| 9. Round | 27/08/2021 | Cusco FC | - | Cienciano | 3:0 dec. | ||||
| 10. Round | 11/09/2021 | Ayacucho FC | - | Cusco FC | 1:3 |  |
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| 11. Round | 17/09/2021 | Cusco FC | - | Alianza Lima | 0:2 | ||||
| 12. Round | 22/09/2021 | Sport Boys | - | Cusco FC | 3:2 | ||||
| 13. Round | 27/09/2021 | Cusco FC | - | Academia Cantolao | 3:2 | ||||
| 14. Round | 03/10/2021 | Universidad San Martín | - | Cusco FC | 1:1 | ||||
| 15. Round | 18/10/2021 | Cusco FC | - | Deportivo Municipal | 3:5 |
Peru