| 1. Round | 18/07/2010 | Club Olimpia | - | Sport Colombia | 3:0 | ||||
| 2. Round | 24/07/2010 | Club Rubio Ñu | - | Sport Colombia | 1:0 | ||||
| 3. Round | 01/08/2010 | Sport Colombia | - | Libertad | 1:0 | ||||
| 4. Round | 07/08/2010 | 3 de Febrero | - | Sport Colombia | 0:3 | ||||
| 5. Round | 14/08/2010 | Sport Colombia | - | Guaraní | 1:1 |  |
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| 7. Round | 29/08/2010 | Sport Colombia | - | Club Nacional | 1:2 | ||||
| 17. Round | 30/10/2010 | Tacuary | - | Sport Colombia | 2:1 |
Paraguay