| 1. Round | 09/07/2023 | Cerro Porteño | - | Guaireña FC | 1:3 |  |
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| 2. Round | 17/07/2023 | Guaireña FC | - | Sportivo Luqueño | 2:2 | ||||
| 4. Round | 30/07/2023 | Guaireña FC | - | Tacuary | 1:2 | ||||
| 7. Round | 19/08/2023 | Club Olimpia | - | Guaireña FC | 1:1 | ||||
| 9. Round | 02/09/2023 | Guaireña FC | - | General Caballero DJLM | 2:1 | ||||
| 11. Round | 15/09/2023 | Guaireña FC | - | Sportivo Trinidense | 2:0 | |
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| 12. Round | 23/09/2023 | Guaireña FC | - | Cerro Porteño | 1:4 | |
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| 13. Round | 02/10/2023 | Sportivo Luqueño | - | Guaireña FC | 1:0 | ||||
| 14. Round | 07/10/2023 | Guaireña FC | - | Libertad | 1:5 | |
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| 15. Round | 19/10/2023 | Tacuary | - | Guaireña FC | 1:3 | |
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| 16. Round | 22/10/2023 | Guaireña FC | - | Club Nacional | 0:0 | ||||
| 17. Round | 29/10/2023 | Guaraní | - | Guaireña FC | 0:0 | ||||
| 18. Round | 03/11/2023 | Guaireña FC | - | Club Olimpia | 0:1 | ||||
| 19. Round | 07/11/2023 | Guaireña FC | - | Sportivo Ameliano | 2:2 | ||||
| 20. Round | 11/11/2023 | General Caballero DJLM | - | Guaireña FC | 0:0 | ||||
| 21. Round | 23/11/2023 | Guaireña FC | - | Resistencia SC | 4:1 | |
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| 22. Round | 29/11/2023 | Sportivo Trinidense | - | Guaireña FC | 7:2 |
Paraguay