| 1. Round | 21/01/2022 | Marathón | - | Platense | 1:0 | ||||
| 2. Round | 23/01/2022 | Platense | - | Real España | 2:1 | ||||
| 3. Round | 06/02/2022 | Platense | - | Victoria | 0:2 |  |
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| 4. Round | 10/02/2022 | Lobos UPNFM | - | Platense | 1:2 | ||||
| 5. Round | 13/02/2022 | Platense | - | Vida | 1:2 | ||||
| 6. Round | 20/02/2022 | Real Sociedad | - | Platense | 1:1 | |
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| 7. Round | 27/02/2022 | Motagua | - | Platense | 2:0 | ||||
| 8. Round | 03/03/2022 | Platense | - | Olimpia | 0:3 | |
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| 10. Round | 13/03/2022 | Victoria | - | Platense | 0:1 | ||||
| 12. Round | 03/04/2022 | Platense | - | Lobos UPNFM | 1:0 | ||||
| 14. Round | 11/04/2022 | Platense | - | Real Sociedad | 1:0 | |
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| 16. Round | 21/04/2022 | Platense | - | Marathón | 1:0 | ||||
| 18. Round | 01/05/2022 | Honduras Progreso | - | Platense | 3:1 |
Honduras