| 2. Round | 25/07/2022 | AD San Carlos | - | Municipal Pérez Zeledón | 2:1 |  |
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| 3. Round | 31/07/2022 | Municipal Pérez Zeledón | - | Municipal Grecia | 2:3 | ||||
| 4. Round | 06/08/2022 | Puntarenas FC | - | Municipal Pérez Zeledón | 1:0 | ||||
| 5. Round | 12/08/2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 2:1 | ||||
| 6. Round | 16/08/2022 | Municipal Pérez Zeledón | - | Puntarenas FC | 1:2 |  |
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| 7. Round | 21/08/2022 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 4:0 | ||||
| 8. Round | 28/08/2022 | Municipal Pérez Zeledón | - | AD San Carlos | 0:2 | ||||
| 9. Round | 02/09/2022 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 10. Round | 05/09/2022 | Municipal Grecia | - | Municipal Pérez Zeledón | 2:3 | ||||
| 11. Round | 11/09/2022 | Municipal Pérez Zeledón | - | Guadalupe | 2:1 | ||||
| 12. Round | 17/09/2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:2 | ||||
| 13. Round | 22/09/2022 | LD Alajuelense | - | Municipal Pérez Zeledón | 1:0 | ||||
| 14. Round | 25/09/2022 | Municipal Pérez Zeledón | - | CS Herediano | 1:3 | ||||
| 15. Round | 30/09/2022 | Santos de Guápiles | - | Municipal Pérez Zeledón | 1:1 | ||||
| 16. Round | 03/10/2022 | Municipal Pérez Zeledón | - | Sporting FC | 1:0 | |
Costa Rica