| 1. Round | 03/06/2021 | Atenas | - | Rampla Juniors | 1:1 |  |
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| 2. Round | 10/06/2021 | Rampla Juniors | - | Racing | 2:2 |  |
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| 3. Round | 16/06/2021 | Villa Teresa | - | Rampla Juniors | 0:1 | |
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| 6. Round | 08/07/2021 | Rampla Juniors | - | Albion | 0:1 | ||||
| 7. Round | 15/07/2021 | Rampla Juniors | - | Danubio | 0:0 | ||||
| 8. Round | 22/07/2021 | Rocha | - | Rampla Juniors | 2:0 | |
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| 9. Round | 31/07/2021 | Rampla Juniors | - | CA Cerro | 0:1 | ||||
| 10. Round | 05/08/2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Round | 12/08/2021 | Rampla Juniors | - | Central Español | 2:1 | |
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| 12. Round | 15/09/2021 | Rampla Juniors | - | Atenas | 2:1 | |
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| 14. Round | 29/09/2021 | Rampla Juniors | - | Villa Teresa | 0:0 | ||||
| 15. Round | 05/10/2021 | Juventud de Las Piedras | - | Rampla Juniors | 1:1 | |
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| 16. Round | 12/10/2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 | ||||
| 17. Round | 19/10/2021 | Albion | - | Rampla Juniors | 2:0 | ||||
| 18. Round | 27/10/2021 | Danubio | - | Rampla Juniors | 2:0 | ||||
| 19. Round | 01/11/2021 | Rampla Juniors | - | Rocha | 2:1 | |
Colombia