| 23. Round | 10/02/2006 | Bayer Leverkusen II | - | VfL Osnabrück | 1:0 | ||||
| 24. Round | 18/02/2006 | SG Wattenscheid 09 | - | Bayer Leverkusen II | 3:2 | ||||
| 25. Round | 22/02/2006 | Bayer Leverkusen II | - | Rot-Weiss Essen | 1:1 |  |
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| 27. Round | 11/03/2006 | Bayer Leverkusen II | - | FC St. Pauli | 2:1 | ||||
| 29. Round | 26/03/2006 | Bayer Leverkusen II | - | Werder Bremen II | 2:1 | ||||
| 26. Round | 29/03/2006 | 1. FC Köln II | - | Bayer Leverkusen II | 5:0 | ||||
| 30. Round | 01/04/2006 | Rot-Weiß Erfurt | - | Bayer Leverkusen II | 3:1 | |
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| 32. Round | 15/04/2006 | VfB Lübeck | - | Bayer Leverkusen II | 3:0 | ||||
| 33. Round | 22/04/2006 | Bayer Leverkusen II | - | Fortuna Düsseldorf | 2:3 | |
Croatia