| 2. Round | 09/07/2022 | Deportivo Coopsol | - | Santos FC | 0:1 | ||||
| 3. Round | 17/07/2022 | Santos FC | - | Unión Huaral | 1:0 | ||||
| 4. Round | 23/07/2022 | Juan Aurich | - | Santos FC | 0:1 | ||||
| 5. Round | 31/07/2022 | Santos FC | - | Alianza Universidad | 2:2 | ||||
| 6. Round | 07/08/2022 | Comerciantes Unidos | - | Santos FC | 1:1 |
Peru