| 1. Round | 14/03/2022 | FC Botoşani | - | Gaz Metan Mediaş | 5:0 | ||||
| 3. Round | 02/04/2022 | Rapid Bucureşti | - | FC Botoşani | 3:0 | ||||
| 4. Round | 10/04/2022 | FC Botoşani | - | Sepsi OSK | 0:1 | ||||
| 6. Round | 25/04/2022 | FC Botoşani | - | FC Universitatea Craiova | 2:1 |  |
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| 7. Round | 02/05/2022 | CS Mioveni | - | FC Botoşani | 0:2 | |
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| 8. Round | 06/05/2022 | FC Botoşani | - | Dinamo Bucureşti | 2:3 | ||||
| 9. Round | 16/05/2022 | Academica Clinceni | - | FC Botoşani | 0:4 |
France