| 2. Round | 06/08/2022 | Cerro Largo | - | Montevideo Wanderers | 1:1 | ||||
| 3. Round | 11/08/2022 | Montevideo Wanderers | - | Fénix | 2:1 | ||||
| 6. Round | 20/08/2022 | Nacional | - | Montevideo Wanderers | 2:0 |  |
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| 5. Round | 27/08/2022 | Montevideo Wanderers | - | Albion | 0:0 | ||||
| 7. Round | 10/09/2022 | Montevideo Wanderers | - | Danubio | 0:3 | ||||
| 8. Round | 13/09/2022 | Deportivo Maldonado | - | Montevideo Wanderers | 1:0 | |
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| 9. Round | 17/09/2022 | Montevideo Wanderers | - | Rentistas | 1:0 | ||||
| 10. Round | 24/09/2022 | Liverpool | - | Montevideo Wanderers | 1:1 | ||||
| 11. Round | 02/10/2022 | Montevideo Wanderers | - | Peñarol | 0:2 | |
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| 12. Round | 09/10/2022 | Montevideo City Torque | - | Montevideo Wanderers | 1:0 | |
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| 13. Round | 14/10/2022 | Montevideo Wanderers | - | Cerrito | 2:1 | ||||
| 15. Round | 24/10/2022 | Boston River | - | Montevideo Wanderers | 2:2 | |
Colombia