| 1. Round | 23/01/2022 | Independiente Medellín | - | Deportes Tolima | 1:0 | ||||
| 2. Round | 26/01/2022 | Deportivo Cali | - | Deportes Tolima | 0:1 | ||||
| 3. Round | 01/02/2022 | Deportes Tolima | - | Unión Magdalena | 2:1 | ||||
| 4. Round | 04/02/2022 | Atlético Nacional | - | Deportes Tolima | 0:1 |  |
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| 8. Round | 21/02/2022 | La Equidad | - | Deportes Tolima | 0:0 | ||||
| 9. Round | 26/02/2022 | Deportes Tolima | - | Atlético Junior | 0:2 | |
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| 10. Round | 08/03/2022 | Cortuluá | - | Deportes Tolima | 1:3 | ||||
| 12. Round | 22/03/2022 | Once Caldas | - | Deportes Tolima | 2:2 | ||||
| 13. Round | 28/03/2022 | Deportes Tolima | - | América de Cali | 1:0 |
Colombia