| 4. Round | 24/07/2022 | Deportes Tolima | - | Atlético Nacional | 2:2 |  |
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| 7. Round | 13/08/2022 | Santa Fe | - | Deportes Tolima | 2:1 | ||||
| 10. Round | 04/09/2022 | Deportes Tolima | - | Cortuluá | 0:0 | ||||
| 11. Round | 10/09/2022 | Patriotas FC | - | Deportes Tolima | 1:1 | |
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| 12. Round | 17/09/2022 | Deportes Tolima | - | Once Caldas | 1:0 | ||||
| 13. Round | 22/09/2022 | América de Cali | - | Deportes Tolima | 0:0 | ||||
| 15. Round | 02/10/2022 | Águilas Doradas | - | Deportes Tolima | 1:2 |
Colombia