3. Round | 04/08/2021 | Once Caldas | - | Independiente Medellín | 1:3 | ||||
Round of 16 | 26/08/2021 | Deportivo Cali | - | Independiente Medellín | 2:2 | ||||
Round of 16 | 03/09/2021 | Independiente Medellín | - | Deportivo Cali | 1:3 |
3. Round | 04/08/2021 | Once Caldas | - | Independiente Medellín | 1:3 | ||||
Round of 16 | 26/08/2021 | Deportivo Cali | - | Independiente Medellín | 2:2 | ||||
Round of 16 | 03/09/2021 | Independiente Medellín | - | Deportivo Cali | 1:3 |