| 2. Round | 23/01/2021 | Independiente Medellín | - | Patriotas FC | 2:1 | ||||
| 4. Round | 05/02/2021 | Independiente Medellín | - | Millonarios | 0:0 | ||||
| 6. Round | 14/02/2021 | Independiente Medellín | - | Jaguares de Córdoba | 1:0 | ||||
| 7. Round | 17/02/2021 | Independiente Medellín | - | Boyacá Chicó | 1:0 |  |
|||
| 8. Round | 21/02/2021 | Santa Fe | - | Independiente Medellín | 0:0 | ||||
| 9. Round | 26/02/2021 | Independiente Medellín | - | Deportivo Cali | 1:1 | ||||
| 10. Round | 28/02/2021 | Envigado FC | - | Independiente Medellín | 1:1 | ||||
| 11. Round | 05/03/2021 | Independiente Medellín | - | La Equidad | 1:1 | ||||
| 12. Round | 14/03/2021 | Águilas Doradas | - | Independiente Medellín | 0:2 | ||||
| 13. Round | 21/03/2021 | Independiente Medellín | - | Deportivo Pasto | 2:2 | |
|||
| 14. Round | 24/03/2021 | América de Cali | - | Independiente Medellín | 1:2 | ||||
| 15. Round | 28/03/2021 | Independiente Medellín | - | Atlético Nacional | 0:0 | ||||
| 18. Round | 10/04/2021 | Independiente Medellín | - | Alianza Petrolera | 2:2 | ||||
| 19. Round | 18/04/2021 | Once Caldas | - | Independiente Medellín | 2:0 |
Colombia