| 1. Round | 18/01/2021 | Deportes Tolima | - | Once Caldas | 1:1 |  |
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| 5. Round | 07/02/2021 | Deportes Tolima | - | Independiente Medellín | 2:1 | ||||
| 6. Round | 15/02/2021 | Deportivo Pasto | - | Deportes Tolima | 0:1 | ||||
| 8. Round | 20/02/2021 | Deportes Tolima | - | Patriotas FC | 3:1 | ||||
| 9. Round | 25/02/2021 | Alianza Petrolera | - | Deportes Tolima | 0:5 | |
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| 10. Round | 28/02/2021 | Deportes Tolima | - | Águilas Doradas | 1:0 |
Colombia