| 3. Round | 01/02/2022 | Deportes Tolima | - | Unión Magdalena | 2:1 | ||||
| 8. Round | 21/02/2022 | La Equidad | - | Deportes Tolima | 0:0 | ||||
| 9. Round | 26/02/2022 | Deportes Tolima | - | Atlético Junior | 0:2 |  |
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| 10. Round | 08/03/2022 | Cortuluá | - | Deportes Tolima | 1:3 |  |
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| 11. Round | 16/03/2022 | Deportes Tolima | - | Patriotas FC | 1:2 | ||||
| 12. Round | 22/03/2022 | Once Caldas | - | Deportes Tolima | 2:2 | ||||
| 13. Round | 28/03/2022 | Deportes Tolima | - | América de Cali | 1:0 | ||||
| 17. Round | 25/04/2022 | Alianza Petrolera | - | Deportes Tolima | 0:2 | |
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| 18. Round | 01/05/2022 | Deportes Tolima | - | Cortuluá | 3:2 | |
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| 19. Round | 09/05/2022 | Millonarios | - | Deportes Tolima | 0:0 |
Colombia