| 1. Round | 11/07/2022 | Deportes Tolima | - | Independiente Medellín | 1:1 |  |
|||
| 16. Round | 09/10/2022 | Deportivo Pasto | - | Deportes Tolima | 2:1 | ||||
| 17. Round | 13/10/2022 | Deportes Tolima | - | Alianza Petrolera | 2:0 | ||||
| 18. Round | 16/10/2022 | Cortuluá | - | Deportes Tolima | 0:1 | ||||
| 20. Round | 29/10/2022 | Envigado FC | - | Deportes Tolima | 1:1 |
Colombia