| 3. Round | 10/08/2021 | Unión Magdalena | - | Cortuluá | 2:0 | ||||
| 4. Round | 17/08/2021 | Cortuluá | - | Boca Juniors de Cali | 3:1 | ||||
| 6. Round | 29/08/2021 | Cortuluá | - | Leones FC | 1:0 | ||||
| 9. Round | 18/09/2021 | Barranquilla FC | - | Cortuluá | 2:2 | ||||
| 11. Round | 03/10/2021 | Atlético FC | - | Cortuluá | 0:2 |  |
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| 12. Round | 11/10/2021 | Cortuluá | - | Orsomarso SC | 1:1 | ||||
| 13. Round | 19/10/2021 | Valledupar FC | - | Cortuluá | 1:2 |
Colombia