| 1. Round | 23/01/2022 | Independiente Medellín | - | Deportes Tolima | 1:0 | ||||
| 2. Round | 27/01/2022 | Patriotas FC | - | Independiente Medellín | 2:0 | ||||
| 3. Round | 30/01/2022 | Independiente Medellín | - | Deportivo Cali | 2:0 | ||||
| 4. Round | 05/02/2022 | Once Caldas | - | Independiente Medellín | 2:1 | ||||
| 20. Round | 15/05/2022 | Independiente Medellín | - | Deportivo Pasto | 1:0 |
Colombia