| 1. Round | 03/08/2011 | Universidad Cesar Vallejo | - | Santa Fe | 1:1 |  |
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| Round of 16 | 30/09/2011 | Botafogo - RJ | - | Santa Fe | 1:1 | ||||
| Round of 16 | 26/10/2011 | Santa Fe | - | Botafogo - RJ | 4:1 | ||||
| Quarter-finals | 02/11/2011 | Santa Fe | - | Vélez Sarsfield | 1:1 | |
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| Quarter-finals | 11/11/2011 | Vélez Sarsfield | - | Santa Fe | 3:2 |
Colombia