| 4. Round | 01/08/2022 | Fortaleza FC | - | Bogotá FC | 1:2 | ||||
| 5. Round | 04/08/2022 | Atlético Huila | - | Fortaleza FC | 1:2 | ||||
| 6. Round | 07/08/2022 | Fortaleza FC | - | Real Cartagena | 3:1 | ||||
| 8. Round | 21/08/2022 | Fortaleza FC | - | Atlético FC | 2:0 | ||||
| 9. Round | 27/08/2022 | Fortaleza FC | - | Boyacá Chicó | 1:0 |  |
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| 10. Round | 02/09/2022 | Leones FC | - | Fortaleza FC | 1:1 | ||||
| 11. Round | 07/09/2022 | Fortaleza FC | - | Barranquilla FC | 3:0 | ||||
| 12. Round | 11/09/2022 | Boca Juniors de Cali | - | Fortaleza FC | 0:0 | ||||
| 13. Round | 16/09/2022 | Fortaleza FC | - | Llaneros FC | 1:0 |
Colombia