| 1. Round | 30/07/2012 | Millonarios | - | Santa Fe | 2:0 |  |
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| 2. Round | 05/08/2012 | Santa Fe | - | Deportes Tolima | 2:1 | ||||
| 3. Round | 14/08/2012 | Cúcuta Deportivo | - | Santa Fe | 4:0 | |
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| 4. Round | 18/08/2012 | Santa Fe | - | Independiente Medellín | 1:1 | ||||
| 5. Round | 26/08/2012 | Deportes Quindío | - | Santa Fe | 1:0 | |
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| 8. Round | 16/09/2012 | Santa Fe | - | Patriotas FC | 2:1 | |
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| 9. Round | 22/09/2012 | Santa Fe | - | Millonarios | 1:2 | |
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| 10. Round | 27/09/2012 | Atlético Junior | - | Santa Fe | 1:1 | ||||
| 11. Round | 30/09/2012 | Atlético Huila | - | Santa Fe | 2:0 | |
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| 13. Round | 07/10/2012 | Atlético Nacional | - | Santa Fe | 2:2 | ||||
| 14. Round | 14/10/2012 | Santa Fe | - | Once Caldas | 2:0 | |
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| 15. Round | 20/10/2012 | Real Cartagena | - | Santa Fe | 2:1 |  |
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| 17. Round | 03/11/2012 | Itagüi Ditaires | - | Santa Fe | 0:0 | |
Colombia