| 1. Round | 16/01/2022 | Platense Zacatecoluca | - | Santa Tecla FC | 0:1 | ||||
| 2. Round | 23/01/2022 | Municipal Limeño | - | Platense Zacatecoluca | 2:1 | ||||
| 3. Round | 26/01/2022 | Platense Zacatecoluca | - | Atlético Marte | 1:1 | ||||
| 5. Round | 06/02/2022 | Platense Zacatecoluca | - | AD Chalatenango | 1:1 | ||||
| 6. Round | 10/02/2022 | Luis Ángel Firpo | - | Platense Zacatecoluca | 1:1 |  |
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| 8. Round | 20/02/2022 | Platense Zacatecoluca | - | Once Municipal | 1:0 |  |
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| 9. Round | 24/02/2022 | CD Águila | - | Platense Zacatecoluca | 2:2 | |
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| 10. Round | 27/02/2022 | Platense Zacatecoluca | - | Jocoro FC | 2:0 | ||||
| 11. Round | 06/03/2022 | FAS | - | Platense Zacatecoluca | 2:1 | |
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| 12. Round | 13/03/2022 | Santa Tecla FC | - | Platense Zacatecoluca | 0:1 | |
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| 13. Round | 20/03/2022 | Platense Zacatecoluca | - | Municipal Limeño | 1:0 | ||||
| 14. Round | 23/03/2022 | Atlético Marte | - | Platense Zacatecoluca | 0:1 | |
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| 15. Round | 03/04/2022 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | |
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| 19. Round | 24/04/2022 | Once Municipal | - | Platense Zacatecoluca | 1:2 |
Colombia