| 1. Round | 05/02/2019 | Boyacá Chicó | - | Deportes Quindío | 1:1 | ||||
| 3. Round | 17/02/2019 | Cortuluá | - | Deportes Quindío | 1:3 | ||||
| 4. Round | 22/02/2019 | Deportes Quindío | - | Leones FC | 0:0 | ||||
| 5. Round | 24/02/2019 | Real Cartagena | - | Deportes Quindío | 2:1 |  |
|||
| 6. Round | 04/03/2019 | Deportes Quindío | - | Boca Juniors de Cali | 2:1 | ||||
| 7. Round | 10/03/2019 | Real San Andrés | - | Deportes Quindío | 1:1 | ||||
| 8. Round | 19/03/2019 | Deportes Quindío | - | Orsomarso SC | 1:1 | |
|||
| 9. Round | 24/03/2019 | Valledupar FC | - | Deportes Quindío | 0:1 |  |
|||
| 14. Round | 28/04/2019 | Fortaleza FC | - | Deportes Quindío | 0:2 | ||||
| 15. Round | 04/05/2019 | Deportes Quindío | - | Llaneros FC | 1:0 |
Colombia