| 2. Round | 13/07/2022 | Millonarios | - | Atlético Bucaramanga | 0:0 | ||||
| 3. Round | 17/07/2022 | Atlético Nacional | - | Millonarios | 1:2 | ||||
| 4. Round | 23/07/2022 | Millonarios | - | Envigado FC | 1:0 | ||||
| 5. Round | 01/08/2022 | Unión Magdalena | - | Millonarios | 0:2 | ||||
| 6. Round | 07/08/2022 | Millonarios | - | Deportivo Cali | 4:2 | ||||
| 8. Round | 21/08/2022 | Millonarios | - | Jaguares de Córdoba | 2:0 |  |
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| 9. Round | 28/08/2022 | Cortuluá | - | Millonarios | 1:4 | ||||
| 10. Round | 04/09/2022 | Millonarios | - | Santa Fe | 2:0 | ||||
| 11. Round | 11/09/2022 | Once Caldas | - | Millonarios | 2:1 | ||||
| 14. Round | 24/09/2022 | Millonarios | - | América de Cali | 2:2 | ||||
| 17. Round | 06/10/2022 | Santa Fe | - | Millonarios | 3:2 |
Colombia