| 3. Round | 20/02/2022 | Árabe Unido | - | Sporting San Miguelito | 0:0 |  |
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| 4. Round | 27/02/2022 | Alianza | - | Sporting San Miguelito | 0:1 | ||||
| 5. Round | 05/03/2022 | Sporting San Miguelito | - | Potros del Este | 1:1 | ||||
| 6. Round | 08/03/2022 | UD Universitario | - | Sporting San Miguelito | 0:2 |  |
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| 7. Round | 13/03/2022 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 8. Round | 19/03/2022 | Veraguas United | - | Sporting San Miguelito | 1:2 | ||||
| 9. Round | 26/03/2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 10. Round | 04/04/2022 | Sporting San Miguelito | - | Atlético Chiriquí | 4:1 | |
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| 11. Round | 09/04/2022 | Sporting San Miguelito | - | Independiente de La Chorrera | 2:1 | |
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| 14. Round | 27/04/2022 | Sporting San Miguelito | - | Árabe Unido | 1:0 | ||||
| 15. Round | 30/04/2022 | Sporting San Miguelito | - | Alianza | 1:0 | ||||
| 12. Round | 04/05/2022 | Sporting San Miguelito | - | Tauro FC | 0:1 | ||||
| 16. Round | 07/05/2022 | Potros del Este | - | Sporting San Miguelito | 0:3 | |
Panama