| 1. Round | 20/02/2021 | San Francisco FC | - | Atlético Chiriquí | 4:4 |  |
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| 9. Round | 04/04/2021 | Alianza | - | San Francisco FC | 1:1 | |
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| 10. Round | 10/04/2021 | San Francisco FC | - | Sporting San Miguelito | 2:0 | ||||
| 11. Round | 15/04/2021 | Árabe Unido | - | San Francisco FC | 1:1 | ||||
| 12. Round | 21/04/2021 | Atlético Chiriquí | - | San Francisco FC | 3:0 |
Panama