| 2. Round | 29/01/2006 | Santos Laguna | - | Atlante | 3:4 | ||||
| 3. Round | 02/02/2006 | UANL Tigres | - | Santos Laguna | 1:0 |  |
|||
| 4. Round | 05/02/2006 | Santos Laguna | - | Dorados de Sinaloa | 1:1 | ||||
| 5. Round | 12/02/2006 | Santos Laguna | - | CF América | 2:2 | ||||
| 6. Round | 19/02/2006 | Deportivo Guadalajara | - | Santos Laguna | 1:1 | ||||
| 7. Round | 26/02/2006 | Santos Laguna | - | Club Necaxa | 1:1 | |
|||
| 8. Round | 05/03/2006 | Club San Luis | - | Santos Laguna | 1:1 | |
|||
| 9. Round | 12/03/2006 | Santos Laguna | - | Veracruz (old) | 0:2 | ||||
| 16. Round | 23/04/2006 | Deportivo Toluca | - | Santos Laguna | 1:2 |
Colombia