| 4. Round | 13/02/2022 | Real Santander | - | Barranquilla FC | 2:3 | ||||
| 8. Round | 10/03/2022 | Orsomarso SC | - | Barranquilla FC | 2:1 | ||||
| 10. Round | 26/03/2022 | Deportes Quindío | - | Barranquilla FC | 2:1 | ||||
| 12. Round | 11/04/2022 | Boca Juniors de Cali | - | Barranquilla FC | 0:0 | ||||
| 14. Round | 25/04/2022 | Tigres FC | - | Barranquilla FC | 2:0 |
Colombia