| 9. Round | 21/02/2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 |  |
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| 10. Round | 01/03/2021 | AD San Carlos | - | Limón FC | 0:3 | ||||
| 11. Round | 04/03/2021 | Deportivo Saprissa | - | AD San Carlos | 1:1 | ||||
| 12. Round | 08/03/2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 13. Round | 13/03/2021 | CS Herediano | - | AD San Carlos | 0:1 | ||||
| 14. Round | 20/03/2021 | Guadalupe | - | AD San Carlos | 1:2 | ||||
| 16. Round | 05/04/2021 | Sporting FC | - | AD San Carlos | 2:0 | ||||
| 17. Round | 10/04/2021 | CS Cartaginés | - | AD San Carlos | 1:1 |  |
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| 18. Round | 19/04/2021 | AD San Carlos | - | Santos de Guápiles | 1:0 | |
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| 19. Round | 22/04/2021 | Municipal Grecia | - | AD San Carlos | 2:1 | ||||
| 20. Round | 27/04/2021 | AD San Carlos | - | Municipal Pérez Zeledón | 0:1 | ||||
| 21. Round | 01/05/2021 | Limón FC | - | AD San Carlos | 0:3 | |
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| 22. Round | 13/05/2021 | AD San Carlos | - | Deportivo Saprissa | 2:0 |
Costa Rica
Nicaragua