| 5. Round | 07/02/2022 | Alianza Petrolera | - | Jaguares de Córdoba | 2:0 | ||||
| 6. Round | 12/02/2022 | Atlético Nacional | - | Alianza Petrolera | 0:0 |  |
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| 7. Round | 17/02/2022 | Alianza Petrolera | - | Cortuluá | 0:0 | ||||
| 8. Round | 20/02/2022 | Deportivo Cali | - | Alianza Petrolera | 1:1 | |
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| 9. Round | 01/03/2022 | Deportivo Pasto | - | Alianza Petrolera | 1:1 | ||||
| 10. Round | 06/03/2022 | Alianza Petrolera | - | Atlético Bucaramanga | 2:2 | |
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| 11. Round | 19/03/2022 | Alianza Petrolera | - | Águilas Doradas | 2:1 | ||||
| 12. Round | 23/03/2022 | La Equidad | - | Alianza Petrolera | 2:1 | ||||
| 13. Round | 27/03/2022 | Alianza Petrolera | - | Patriotas FC | 2:1 | ||||
| 14. Round | 03/04/2022 | Atlético Junior | - | Alianza Petrolera | 3:1 | ||||
| 15. Round | 11/04/2022 | Alianza Petrolera | - | Independiente Medellín | 1:1 | |
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| 16. Round | 16/04/2022 | Santa Fe | - | Alianza Petrolera | 0:1 |
Colombia