| 1. Round | 16/02/2021 | Lobos UPNFM | - | Motagua | 1:2 | ||||
| 4. Round | 27/02/2021 | Lobos UPNFM | - | Real de Minas | 2:0 |  |
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| 5. Round | 04/03/2021 | Honduras Progreso | - | Lobos UPNFM | 0:3 |  |
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| 6. Round | 07/03/2021 | Motagua | - | Lobos UPNFM | 3:1 | ||||
| 8. Round | 17/03/2021 | Lobos UPNFM | - | Olimpia | 2:1 | ||||
| 9. Round | 20/03/2021 | Real de Minas | - | Lobos UPNFM | 0:3 | ||||
| 2. Round | 24/03/2021 | Real Sociedad | - | Lobos UPNFM | 1:1 | |
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| 7. Round | 29/03/2021 | Lobos UPNFM | - | Real Sociedad | 1:2 | ||||
| 10. Round | 01/04/2021 | Lobos UPNFM | - | Honduras Progreso | 0:2 | ||||
| 11. Round | 09/04/2021 | Marathón | - | Lobos UPNFM | 1:1 | ||||
| 12. Round | 18/04/2021 | Lobos UPNFM | - | Platense | 0:0 | ||||
| 13. Round | 22/04/2021 | Real España | - | Lobos UPNFM | 1:1 | ||||
| 14. Round | 28/04/2021 | Lobos UPNFM | - | Vida | 3:1 | |
Honduras