| 1. Round | 03/02/2025 | Leones FC | - | Boca Juniors de Cali | 1:1 | ||||
| 2. Round | 09/02/2025 | Orsomarso SC | - | Leones FC | 2:3 | ||||
| 3. Round | 17/02/2025 | Leones FC | - | Real Cartagena | 1:2 |  |
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| 5. Round | 03/03/2025 | Tigres FC | - | Leones FC | 1:1 | ||||
| 6. Round | 12/03/2025 | Leones FC | - | Internacional de Palmira | 1:2 | ||||
| 7. Round | 17/03/2025 | Real Santander | - | Leones FC | 1:0 | ||||
| 8. Round | 25/03/2025 | Leones FC | - | Real Soacha Cundinamarca | 3:1 | ||||
| 9. Round | 28/03/2025 | Jaguares de Córdoba | - | Leones FC | 2:0 | ||||
| 10. Round | 06/04/2025 | Leones FC | - | Deportes Quindío | 4:1 | ||||
| 11. Round | 12/04/2025 | Patriotas FC | - | Leones FC | 3:1 | ||||
| 12. Round | 21/04/2025 | Atlético Huila | - | Leones FC | 2:0 | ||||
| 13. Round | 26/04/2025 | Leones FC | - | Cúcuta Deportivo | 0:1 | ||||
| 14. Round | 05/05/2025 | Leones FC | - | Jaguares de Córdoba | 1:3 | ||||
| 15. Round | 10/05/2025 | Atlético FC | - | Leones FC | 0:0 | ||||
| 16. Round | 17/05/2025 | Leones FC | - | Bogotá FC | 3:0 |  |
Colombia