| 10. Round | 02/03/2025 | Isidro Metapán | - | Alianza | 2:1 | ||||
| 11. Round | 09/03/2025 | Fuerte San Francisco | - | Isidro Metapán | 0:1 | ||||
| 13. Round | 23/03/2025 | Once Deportivo | - | Isidro Metapán | 0:2 | ||||
| 14. Round | 27/03/2025 | Isidro Metapán | - | Municipal Limeño | 0:0 | ||||
| 15. Round | 29/03/2025 | CD Cacahuatique | - | Isidro Metapán | 0:0 | ||||
| 16. Round | 06/04/2025 | Isidro Metapán | - | Platense Zacatecoluca | 2:1 |  |
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| 17. Round | 09/04/2025 | Dragón | - | Isidro Metapán | 2:3 |  |
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| 18. Round | 13/04/2025 | Isidro Metapán | - | FAS | 3:1 | |
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| 19. Round | 20/04/2025 | Luis Ángel Firpo | - | Isidro Metapán | 0:0 | ||||
| 21. Round | 27/04/2025 | Alianza | - | Isidro Metapán | 1:0 | |
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| 22. Round | 03/05/2025 | Isidro Metapán | - | Fuerte San Francisco | 0:1 | |
Colombia