| Group 5 | 25/07/2018 | Club Celaya | - | CF Pachuca | 0:2 | ||||
| Group 5 | 01/08/2018 | CF Pachuca | - | Santos Laguna | 2:0 |  |
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| Group 5 | 30/08/2018 | Santos Laguna | - | CF Pachuca | 0:0 | ||||
| Group 5 | 05/09/2018 | CF Pachuca | - | Club Celaya | 2:0 | ||||
| Round of 16 | 26/09/2018 | CF Pachuca | - | Cafetaleros de Tapachula | 3:0 | ||||
| Quarter-finals | 04/10/2018 | CF Pachuca | - | UANL Tigres | 6:5 pso |
Colombia