| 1. Round | 01/02/2025 | Real Santander | - | Tigres FC | 1:0 |  |
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| 2. Round | 10/02/2025 | Barranquilla FC | - | Real Santander | 1:2 | ||||
| 3. Round | 15/02/2025 | Real Santander | - | Real Soacha Cundinamarca | 3:4 | |
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| 4. Round | 22/02/2025 | Bogotá FC | - | Real Santander | 2:1 | |
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| 7. Round | 17/03/2025 | Real Santander | - | Leones FC | 1:0 |  |
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| 10. Round | 06/04/2025 | Real Santander | - | Orsomarso SC | 0:0 | ||||
| 11. Round | 14/04/2025 | Atlético FC | - | Real Santander | 2:0 | |
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| 12. Round | 19/04/2025 | Real Santander | - | Patriotas FC | 1:1 | ||||
| 13. Round | 27/04/2025 | Deportes Quindío | - | Real Santander | 4:2 | ||||
| 14. Round | 06/05/2025 | Cúcuta Deportivo | - | Real Santander | 2:1 | |
Colombia