| 1. Round | 12/02/2022 | Unión de Santa Fe | - | River Plate | 1:0 | ||||
| 2. Round | 17/02/2022 | River Plate | - | Patronato de Paraná | 4:1 |  |
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| 3. Round | 21/02/2022 | Newell's Old Boys | - | River Plate | 0:2 | |
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| 4. Round | 27/02/2022 | River Plate | - | Racing Club | 2:2 | ||||
| 5. Round | 05/03/2022 | San Lorenzo | - | River Plate | 0:1 | ||||
| 6. Round | 13/03/2022 | River Plate | - | Gimnasia de La Plata | 4:0 | |
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| 7. Round | 20/03/2022 | River Plate | - | Boca Juniors | 0:1 | ||||
| 8. Round | 02/04/2022 | Defensa y Justicia | - | River Plate | 1:2 | ||||
| 9. Round | 10/04/2022 | River Plate | - | Argentinos Juniors | 4:2 | |
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| 10. Round | 18/04/2022 | Banfield | - | River Plate | 1:2 |
Colombia
