| 1. Round | 24/07/2021 | Leones FC | - | Orsomarso SC | 1:0 | ||||
| 2. Round | 31/07/2021 | Valledupar FC | - | Leones FC | 1:1 | ||||
| 3. Round | 09/08/2021 | Leones FC | - | Boyacá Chicó | 0:0 | ||||
| 4. Round | 14/08/2021 | Fortaleza FC | - | Leones FC | 3:1 | ||||
| 5. Round | 20/08/2021 | Leones FC | - | Real Santander | 2:1 |  |
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| 6. Round | 29/08/2021 | Cortuluá | - | Leones FC | 1:0 |
Colombia