| 1. Round | 17/01/2021 | Atlético Junior | - | Independiente Medellín | 1:0 | ||||
| 2. Round | 25/01/2021 | Once Caldas | - | Atlético Junior | 1:2 | ||||
| 3. Round | 31/01/2021 | Atlético Junior | - | América de Cali | 2:1 |  |
|||
| 5. Round | 06/02/2021 | Atlético Junior | - | Alianza Petrolera | 2:0 | ||||
| 6. Round | 14/02/2021 | Envigado FC | - | Atlético Junior | 2:2 | ||||
| 7. Round | 18/02/2021 | Atlético Junior | - | Deportivo Cali | 1:2 |  |
|||
| 8. Round | 21/02/2021 | Boyacá Chicó | - | Atlético Junior | 2:1 | ||||
| 9. Round | 24/02/2021 | Atlético Junior | - | Millonarios | 2:0 | |
|||
| 10. Round | 28/02/2021 | Patriotas FC | - | Atlético Junior | 1:0 | ||||
| 11. Round | 06/03/2021 | Atlético Junior | - | Atlético Bucaramanga | 1:1 | |
|||
| 16. Round | 31/03/2021 | Jaguares de Córdoba | - | Atlético Junior | 0:2 | ||||
| 18. Round | 11/04/2021 | Deportivo Pasto | - | Atlético Junior | 0:0 |
Colombia