| 1. Round | 17/07/2021 | América de Cali | - | Atlético Junior | 3:1 |  |
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| 2. Round | 25/07/2021 | Atlético Junior | - | Envigado FC | 1:0 | |
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| 3. Round | 01/08/2021 | Independiente Medellín | - | Atlético Junior | 0:0 | ||||
| 4. Round | 09/08/2021 | Atlético Junior | - | Deportes Tolima | 0:0 | ||||
| 5. Round | 15/08/2021 | Jaguares de Córdoba | - | Atlético Junior | 1:1 | ||||
| 6. Round | 22/08/2021 | Atlético Junior | - | Once Caldas | 4:2 | ||||
| 7. Round | 29/08/2021 | Deportivo Cali | - | Atlético Junior | 1:1 | ||||
| 8. Round | 23/09/2021 | Atlético Junior | - | Atlético Huila | 3:0 | ||||
| 12. Round | 02/10/2021 | Atlético Junior | - | Patriotas FC | 1:0 | ||||
| 13. Round | 12/10/2021 | Atlético Bucaramanga | - | Atlético Junior | 1:1 | |
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| 16. Round | 29/10/2021 | Atlético Junior | - | Deportes Quindío | 0:0 | ||||
| 17. Round | 01/11/2021 | Atlético Junior | - | Deportivo Pasto | 2:1 |
Colombia