| 4. Round | 03/02/2021 | Alianza Petrolera | - | Águilas Doradas | 1:2 | ||||
| 5. Round | 06/02/2021 | Atlético Junior | - | Alianza Petrolera | 2:0 | ||||
| 6. Round | 12/02/2021 | Alianza Petrolera | - | Once Caldas | 0:0 | ||||
| 7. Round | 16/02/2021 | Patriotas FC | - | Alianza Petrolera | 3:1 | ||||
| 8. Round | 23/02/2021 | Deportivo Cali | - | Alianza Petrolera | 1:1 | ||||
| 9. Round | 25/02/2021 | Alianza Petrolera | - | Deportes Tolima | 0:5 | ||||
| 10. Round | 03/03/2021 | Atlético Nacional | - | Alianza Petrolera | 5:0 | ||||
| 13. Round | 23/03/2021 | Alianza Petrolera | - | Atlético Bucaramanga | 1:3 | ||||
| 19. Round | 17/04/2021 | Alianza Petrolera | - | Envigado FC | 1:1 |
Colombia