| 5. Round | 01/03/2025 | Real Santander | - | Jaguares de Córdoba | 0:1 |  |
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| 6. Round | 09/03/2025 | Real Cartagena | - | Real Santander | 2:0 | |
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| 8. Round | 22/03/2025 | Boca Juniors de Cali | - | Real Santander | 0:1 | ||||
| 9. Round | 31/03/2025 | Real Santander | - | Cúcuta Deportivo | 2:1 | ||||
| 10. Round | 06/04/2025 | Real Santander | - | Orsomarso SC | 0:0 | ||||
| 11. Round | 14/04/2025 | Atlético FC | - | Real Santander | 2:0 | ||||
| 12. Round | 19/04/2025 | Real Santander | - | Patriotas FC | 1:1 |  |
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| 13. Round | 27/04/2025 | Deportes Quindío | - | Real Santander | 4:2 | ||||
| 14. Round | 06/05/2025 | Cúcuta Deportivo | - | Real Santander | 2:1 | |
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| 16. Round | 18/05/2025 | Atlético Huila | - | Real Santander | 0:0 |
Colombia