| 2. Round | 13/07/2022 | Deportivo Pasto | - | Envigado FC | 4:0 | ||||
| 3. Round | 17/07/2022 | Envigado FC | - | Alianza Petrolera | 2:2 |  |
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| 5. Round | 03/08/2022 | Deportivo Cali | - | Envigado FC | 0:3 | ||||
| 6. Round | 06/08/2022 | Envigado FC | - | Unión Magdalena | 1:2 | ||||
| 12. Round | 17/09/2022 | Envigado FC | - | Cortuluá | 3:2 |  |
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| 15. Round | 03/10/2022 | Santa Fe | - | Envigado FC | 1:0 |
Colombia