| 4. Round | 09/08/2021 | Alianza Petrolera | - | Deportivo Pasto | 2:0 | ||||
| 5. Round | 14/08/2021 | Envigado FC | - | Alianza Petrolera | 2:1 | ||||
| 6. Round | 23/08/2021 | Alianza Petrolera | - | Deportivo Cali | 2:3 | ||||
| 9. Round | 12/09/2021 | Santa Fe | - | Alianza Petrolera | 1:1 | ||||
| 19. Round | 14/11/2021 | Millonarios | - | Alianza Petrolera | 1:1 | ||||
| 20. Round | 21/11/2021 | Alianza Petrolera | - | Atlético Junior | 1:1 |
Colombia