| 10. Round | 02/03/2025 | Real Estelí FC | - | Rancho Santana | 3:0 | ||||
| 12. Round | 12/03/2025 | Matagalpa FC | - | Real Estelí FC | 2:4 | ||||
| 14. Round | 29/03/2025 | ART Municipal Jalapa | - | Real Estelí FC | 1:2 | ||||
| 16. Round | 13/04/2025 | Real Estelí FC | - | H&H Export Sébaco | 1:0 | ||||
| 13. Round | 17/04/2025 | Real Estelí FC | - | Club Deportivo Ocotal | 3:2 |  |
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| 18. Round | 02/05/2025 | UNAN Managua | - | Real Estelí FC | 1:2 |
Nicaragua