| 1. Round | 31/07/2010 | Sint-Truidense VV | - | Lierse SK (old) | 1:0 |  |
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| 2. Round | 06/08/2010 | Lierse SK (old) | - | Standard Liège | 1:4 |  |
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| 3. Round | 14/08/2010 | KV Mechelen | - | Lierse SK (old) | 1:0 | ||||
| 4. Round | 21/08/2010 | Lierse SK (old) | - | KV Kortrijk | 1:2 | ||||
| 5. Round | 29/08/2010 | KRC Genk | - | Lierse SK (old) | 4:1 | |
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| 8. Round | 22/09/2010 | Lierse SK (old) | - | RSC Anderlecht | 1:1 | |
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| 9. Round | 25/09/2010 | Sporting Charleroi | - | Lierse SK (old) | 0:1 | |
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| 10. Round | 02/10/2010 | Lierse SK (old) | - | Cercle Brugge | 0:1 | ||||
| 17. Round | 27/11/2010 | Standard Liège | - | Lierse SK (old) | 7:0 | ||||
| 19. Round | 12/12/2010 | KV Kortrijk | - | Lierse SK (old) | 3:1 | ||||
| 20. Round | 18/12/2010 | Lierse SK (old) | - | KRC Genk | 1:1 | ||||
| 22. Round | 29/12/2010 | Lierse SK (old) | - | KVC Westerlo | 2:1 | ||||
| 26. Round | 12/02/2011 | Lierse SK (old) | - | Germinal Beerschot | 2:2 | ||||
| 18. Round | 15/02/2011 | Lierse SK (old) | - | KV Mechelen | 2:1 | |
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| 27. Round | 19/02/2011 | SV Zulte Waregem | - | Lierse SK (old) | 1:1 | ||||
| 28. Round | 06/03/2011 | Lierse SK (old) | - | KAS Eupen | 1:1 | ||||
| 29. Round | 12/03/2011 | Sporting Lokeren | - | Lierse SK (old) | 1:1 | |
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Belgium