| 4. Round | 15/08/2021 | Valledupar FC | - | Tigres FC | 0:0 |  |
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| 6. Round | 28/08/2021 | Fortaleza FC | - | Tigres FC | 2:1 | ||||
| 7. Round | 06/09/2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 8. Round | 10/09/2021 | Cortuluá | - | Tigres FC | 3:0 | ||||
| 9. Round | 22/09/2021 | Tigres FC | - | Unión Magdalena | 0:0 | ||||
| 10. Round | 28/09/2021 | Boca Juniors de Cali | - | Tigres FC | 1:0 | ||||
| 12. Round | 12/10/2021 | Leones FC | - | Tigres FC | 2:0 | ||||
| 13. Round | 18/10/2021 | Tigres FC | - | Llaneros FC | 0:2 |
Colombia